Plaquenil Screening

Posted by in Blog | 5,535 comments

with Dr. Raphael Rosenbaum

Plaquenil Screening

.

.

Plaquenil or Hydroxychloroquine belongs to the quinolone family of drugs.  Historically drugs like chloroquine and hydroxychloroquine were used as malaria prophylaxis treatment.  More recently they have been employed by rheumatologists to treat  rheumatoid arthritis, systemic lupus erythematosus and other autoimmune disease.

It has been known for about 60 years that large doses of chloroquine/hydroxychloroquine could cause retinal toxicity.  With the expanded chronic use of these drugs for rheumatological disorders this has taken on a bigger concern.  Early signs of quinolone induced vision changes include dimness, flickering yellow lights, green or red halos, photophobia, cycloplegia, and diplopia.

As a result annual screening with color vision checks, visual field testing and dilated fundus exams are crucial to asses subtle quinolone induced retinal toxicity that may still be reversible in the early stages.

Leave a Reply