Immunosuppressive Therapy in Uveitis

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with Dr. Raphael Rosenbaum

Being an Ocular Immunologist and Uveitis expert patients often ask me if immunosuppressive therapy is safe.  It should be obvious that  we take such therapy seriously understanding the possible risks that may develop with immunosuppressive drugs.

However, my philosophy is based on my training with Dr. Foster that adverse side effects to prescribed drugs are not tolerated.  If I decide to recommend therapy with an immunosuppressive drug and if you experience adverse effects we will pull the plug on that drug and replace it with an alternative one.  This is done keeping the goal in mind of getting you where you need to be, inflammation free feeling good on an appropriate agent.

Additionally, recent studies in the British Journal of Medicine looking at thousands of patients with Uveitis treated with conventional immunosuppressive therapy did not disclose an increased malignancy rate in patients treated with most steroid sparing immunosuppressive agents.  Exceptions included the alkalyting agents chlorambucil and cyclophosphamide and the data was inconclusive in respect to the anti-TNF agents Remicade, Enbrel and Humira.

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